Apparently doctors noticed people with ChinCOVID getting diabetes. I lost the link, but I think it was 14.4% of COVID-19 patients.
A couple of studies appear to have found the mechanism, and I find it a bit alarming. Here’s one of them, funded by the National Institues for Health.
SARS-CoV-2 infection induces beta cell transdifferentiation
Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19. Single-cell RNA sequencing and immunostaining from ex vivo infections confirmed that multiple types of pancreatic islet cells were susceptible to SARS-CoV-2, eliciting a cellular stress response and the induction of chemokines. Upon SARS-CoV-2 infection, beta cells showed a lower expression of insulin and a higher expression of alpha and acinar cell markers, including glucagon and trypsin1, respectively, suggesting cellular transdifferentiation. Trajectory analysis indicated that SARS-CoV-2 induced eIF2-pathway-mediated beta cell transdifferentiation, a phenotype that could be reversed with trans-integrated stress response inhibitor (trans-ISRIB). Altogether, this study demonstrates an example of SARS-CoV-2 infection causing cell fate change, which provides further insight into the pathomechanisms of COVID-19.
Basically, the insulin-producing cells seem to have the same ACE2 receptor that makes cells in lungs susceptible to SARS-CoV-2. That makes them vulnerable to damage by the antigen.
This makes me wonder about the Pfizer and Moderna pseudo-vaccines that prompt the body to produces the SARS-CoV-2 antigen itself. Are people getting those jabs going to be developing diabetes?
Something to watch for. And perhaps someone will research that possibility.
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